After a failed assassination attempt San Francisco chief of detectives, Robert T. Ironside (Raymond Burr) is left paralyzed from the waist down. However, he continues his work as a private detective with the help of his colleagues after being forced to leave the force.
With his trusty former assistants D.S Ed Brown (Don Galloway) and Eve Whitfield (Barbara Anderson) who was later replaced with Fran Belding (Elizabeth Baur) and former delinquent (and later lawyer) Mark Sanger (Don Mitchell), he combats crime for the San Francisco police from his mobile office (a van) while leaving a pot of chili cooking back at headquarters.
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